The Grenade is an offensive item introduced in Kid Icarus: Uprising. Utilizing this item will throw a grenade in the targeted direction. Upon impact with the ground or an enemy, it will explode, dealing damage to enemies within its blast radius. It is available in both Solo Mode and Together Mode.
Once picked up, you can lob this powerful grenade in the direction of the reticle with your next press of the attack button. The yellow color of the reticle means you can press the attack button to throw an item.